Hox Genes: Master Regulators of the Animal Bodyplan
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Hox Homeotic Selector Genes: Key Regulators of Embryogenesis
The Hox genes are major regulators of the animal bodyplan. They determine the identities of sequential zones along the main body axis. The Hox genes show collinearity– spatial and temporal ordering of their expression corresponding to their genomic ordera spectacular phenomenon that has excited life scientists since its discovery in 1978. Three mechanisms have been proposed to explain this spat...
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" It is impossible to say how the idea first entered my brain; but once conceived, it haunted me day and night. I think it was his eye! yes, it was this! He had the eye of a vulture-"-Edgar Allan Poe, " The TellTale Heart " Strikingly different animals have more in common than meets the eye. Animal architecture is guided by many conserved regulators, among them homeobox genes that have related ...
متن کاملBeyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis.
During the past decade it was recognized that homeobox gene families such as the clustered Hox genes play pivotal roles both in normal and malignant hematopoiesis. More recently, similar roles have also become apparent for members of the ParaHox gene cluster, evolutionarily closely related to the Hox gene cluster. This is in particular found for the caudal-type homeobox genes (Cdx) genes, known...
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BACKGROUND Hox genes control animal body plans by directing the morphogenesis of segment-specific structures. As transcription factors, HOX proteins achieve this through the activation of downstream target genes. Much research has been devoted to the search for these targets and the characterization of their roles in organogenesis. This has shown that the direct targets of Hox activation are of...
متن کاملAberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues.
Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT...
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